‘Certainly, that is certainly about ideal. I hunt for a Actual physical understanding of biological programs in a bottom-up way. I feel you could potentially distinguish three traces of exploration in my group in the meanwhile. The very first worries chromosome composition: how do you obtain a metre-prolonged DNA polymer folded and organised in this kind of microscopic mobile? We've designed visualisation approaches that allow us to study how, by way of example, SMC proteins loop DNA (movie on Youtube) in order to Develop up chromosomes.
It absolutely was only within the nineteen nineties even though, when nanotechnology experienced Sophisticated to the level wherever single molecules may be manipulated, that the first experimental units commenced to appear.
[Laughs] ‘It absolutely was unquestionably an awesome risk! At some time, I had been very well informed that it could go Mistaken and that I could turn out to be much less thriving, but I just disregarded that. Curiosity has normally been my strongest driving drive. And by chance all of it worked out.’
Our operate was promptly adopted up by Some others, most notably by Phaedon Avouris and colleagues at IBM, who in Oct 1998 released their conclusions on transistors constructed from one- and multi-walled carbon nanotubes in Utilized Physics Letters.
2010, formulated a completely new way (‘wedging transfer’) to manipulate nanostructures; very first report of DNA translocation by way of graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into good-point out nanopores
SMC complexes can go Actual physical roadblocks larger than their ring measurement, indicating a nontopological mechanism for DNA loop extrusion
We use https://www.ceesdekker.net nanofabricated microfluidic buildings to sample spatial boundaries for micro organism and biomimetic vesicles with reconstituted protein networks which assess the basic part of spatial confinement on the molecular and cellular level. Our projects include the following:
He also located time to write many books, ship almost forty thousand tweets and direct A prosperous study team at Delft College of Engineering. ‘It doesn’t experience like function’, he suggests. ‘I’m just terribly curious.’
Comprehension elementary procedures regulating the spatial and dynamic organisation with the DNA in Stay cells.
‘The fantastically refined way through which factors in nature functionality under no circumstances ceases to amaze me. If we fix the puzzle of how existence came into remaining, I be expecting that my amazement for the complexity of development may have increased and with it my awe for that greatness on the Creator.’
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Cees Dekker is Distinguished University Professor at TU Delft. Educated as being a physicist, he pioneered nanotechnology with numerous discoveries on carbon nanotubes within the 1990s. Because 2000, he moved to single-molecule biophysics and nanobiology. His current research concentrates on (i) nanopores for protein sequencing; (ii) chromosome composition, specifically SMC motor protein; and (iii) creating a residing synthetic mobile from lifeless molecules. Dekker is really an elected member with the KNAW and fellow to your APS as well as IOP.
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij achieved enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond intelligent layout in 2005. (nl)